So... The White Sox or the Mariners?
On paper, the White Sox actually match up decently to give the Mariners some fits. Their rotation and offense have legitimate stars that could cause problems. Their division has two terrible teams in Kansas City and Detroit that could really boost their record, and ever since the 2000 ALDS, the White Sox have been a thorn in their sides.
That being said, I strongly believe that while the offense may be a push, the rotation of the Mariners has a much higher ceiling, and as long as Hendricks is out, the bullpen will be a massive advantage for Seattle. Cease is really good, but I strongly believe that both Luis Castillo and George Kirby can have better seasons than him in 2023.
There's a path where Chicago enjoys their newfound freedom away from La Russa, and makes a push for a playoff spot that could threaten Seattle. If these two were to meet in a playoff series, the Mariners would be heavy favorites.